Effect of ethanol on adrenaline and noradrenaline secretion of the adrenal gland in the dog.

HIROSE, T., HIGASHI, R., IKEDA, H., TAMIIRA, K. and Suzuxi, T. Effect of Ethanol on Adrenaline anal Noradrenaline Secretion of the Adrenal Glandin the Dog. Tohoku J. exp. Med., 1973, 109 (1), 85-88 Conscious dogs were infused intravenously with ethanol solution in a dose of 0.7-1.0 g/kg. Before and after the ethanol infusion, the adrenal venous blood samples were collected and analyzed for adrenaline and noradrenaline fluorimetrically. In dogs infused with ethanol in a dose of 0.7g/kg, the blood ethanol concentration was elevated to 70120 ma/100 ml. The animals became depressed but did not sleep. No change in adrenaline and noradrenaline secretion of the adrenal gland was observed. In dogs infused with 1.0 g/kg of ethanol, the blood ethanol concentration just after the end of the infusion was 191-241mg/100 ml. The animals lay down and slept deeply. In 3 out of 5 dogs the adrenal medullary secretion rates remainedunal tered and in the other 2 dogs a definite increase in adrenaline and noradrenaline secretion was observed after the administration of ethanol. ------adrenal medullary secretion; adrenaline and noradrenaline secretion rate; blood ethanol concentration